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Assay Detail

CHEMBL5042377

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H] DPCPX from rat adenosine A1 receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A1 (CHEMBL318)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Selective A<sub>3</sub> Adenosine Receptor Antagonist Radioligand for Human and Rodent Species.
Suresh RR, Gao ZG, Salmaso V, Chen E, Campbell RG, Poe RB, Liston TE, Jacobson KA.
ACS Med Chem Lett (2022) 13 : 623 -631
PubMed 35450351 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.48 6.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2181976 1 6.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2181976 Ki = 333.0 nM 6.48