Assay Detail
Binding
CHEMBL5042379
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Displacement of [3H] DPCPX from human adenosine A1 receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective A<sub>3</sub> Adenosine Receptor Antagonist Radioligand for Human and Rodent Species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.12 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5086466 | — | — | 1 | 7.10 |
| CHEMBL2181976 | — | — | 1 | 6.79 |
| CHEMBL5081520 | — | — | 1 | 5.84 |
| CHEMBL5088750 | — | — | 1 | 5.80 |
| CHEMBL5086258 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5086466 | — | Ki | = | 78.7 | nM | 7.10 |
| CHEMBL2181976 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL5081520 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL5088750 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL5086258 | — | Ki | = | 8770.0 | nM | 5.06 |