Assay Detail
Binding
CHEMBL5042749
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Antagonist activity at p38 MAPK alpha (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.32 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | 8.00 |
| CHEMBL4129018 | MW-150 | 2.0 | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4129018 | MW-150 | IC50 | = | 230.0 | nM | 6.64 |