Assay Detail
Functional
CHEMBL5042903
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse MOR expressed in CHO cells assessed as inhibition of DAMGO-induced calcium mobilization preincubated for 60 mins measured after 15 mins by calcium mobilization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.19 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 8.18 |
| CHEMBL5071060 | — | — | 1 | 7.40 |
| CHEMBL5074744 | — | — | 1 | 7.30 |
| CHEMBL5089300 | — | — | 1 | 7.13 |
| CHEMBL5074037 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | IC50 | = | 6.62 | nM | 8.18 |
| CHEMBL5071060 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5074744 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5089300 | — | IC50 | = | 74.4 | nM | 7.13 |
| CHEMBL5074037 | — | IC50 | = | 1103.0 | nM | 5.96 |