Assay Detail
Functional
CHEMBL5042907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HOS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.03 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL584744 | — | — | 1 | 9.11 |
| CHEMBL5074744 | — | — | 1 | 7.24 |
| CHEMBL5071060 | — | — | 1 | 6.90 |
| CHEMBL5089300 | — | — | 1 | 6.01 |
| CHEMBL5074037 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL584744 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL5074744 | — | IC50 | = | 57.5 | nM | 7.24 |
| CHEMBL5071060 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL5089300 | — | IC50 | = | 965.0 | nM | 6.01 |
| CHEMBL5074037 | — | IC50 | = | 1260.0 | nM | 5.90 |