Assay Detail
Binding
CHEMBL5042909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | GHOST CCR5 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.39 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL584744 | — | — | 1 | 7.75 |
| CHEMBL5074744 | — | — | 1 | 7.03 |
| CHEMBL5071060 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL584744 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5074744 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5071060 | — | EC50 | > | 100000.0 | nM | - |