Assay Detail
Functional
CHEMBL5043072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.36 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091313 | — | — | 1 | 7.20 |
| CHEMBL5090481 | — | — | 1 | 6.70 |
| CHEMBL5091281 | — | — | 1 | 6.32 |
| CHEMBL5080971 | — | — | 1 | 6.19 |
| CHEMBL5075342 | — | — | 1 | 5.99 |
| CHEMBL5070084 | — | — | 1 | 5.91 |
| CHEMBL5075319 | — | — | 1 | 5.86 |
| CHEMBL229457 | — | — | 1 | 5.83 |
| CHEMBL5092168 | — | — | 1 | 5.66 |
| CHEMBL5084409 | — | — | 1 | 5.62 |
| CHEMBL5091279 | — | — | 1 | 5.14 |
| CHEMBL5078063 | — | — | 1 | 5.07 |
| CHEMBL5091549 | — | — | 1 | 4.99 |
| CHEMBL5080635 | — | — | 1 | 4.80 |
| CHEMBL5074971 | — | — | 1 | 4.80 |
| CHEMBL5079375 | — | — | 1 | 4.61 |
| CHEMBL5081296 | — | — | 1 | 4.55 |
| CHEMBL5073964 | — | — | 1 | 4.52 |
| CHEMBL5089522 | — | — | 1 | 4.42 |
| CHEMBL5069826 | — | — | 1 | 4.18 |
| CHEMBL957 | BOSENTAN | 4.0 | 1 | 4.17 |
| CHEMBL5083278 | — | — | 1 | - |
| CHEMBL5092133 | — | — | 1 | - |
| CHEMBL5081865 | — | — | 1 | - |
| CHEMBL5083806 | — | — | 1 | - |
| CHEMBL5078229 | — | — | 1 | - |
| CHEMBL5081207 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091313 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5090481 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5091281 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5080971 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5075342 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5070084 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL5075319 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL229457 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL5092168 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5084409 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL5091279 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL5078063 | — | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL5091549 | — | IC50 | = | 10310.0 | nM | 4.99 |
| CHEMBL5080635 | — | IC50 | = | 15920.0 | nM | 4.80 |
| CHEMBL5074971 | — | IC50 | = | 15710.0 | nM | 4.80 |
| CHEMBL5079375 | — | IC50 | = | 24580.0 | nM | 4.61 |
| CHEMBL5081296 | — | IC50 | = | 28190.0 | nM | 4.55 |
| CHEMBL5073964 | — | IC50 | = | 30170.0 | nM | 4.52 |
| CHEMBL5089522 | — | IC50 | = | 38320.0 | nM | 4.42 |
| CHEMBL5069826 | — | IC50 | = | 65340.0 | nM | 4.18 |
| CHEMBL957 | BOSENTAN | IC50 | = | 67360.0 | nM | 4.17 |
| CHEMBL5083278 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5092133 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5081865 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5083806 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5078229 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5081207 | — | IC50 | > | 80000.0 | nM | - |