Assay Detail
Binding
CHEMBL5043233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to wild-type human full length BMX (M1 to H675 residues) expressed in bacterial expression system by Kinomescan method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cytoplasmic tyrosine-protein kinase BMX (CHEMBL3834) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 7.06 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083772 | BIIB-091 | 2.0 | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083772 | BIIB-091 | Kd | = | 88.0 | nM | 7.06 |