Assay Detail
Binding
CHEMBL5043682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BuChE (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.69 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081032 | — | — | 1 | 8.74 |
| CHEMBL362444 | — | — | 1 | 8.40 |
| CHEMBL5090683 | — | — | 1 | 8.22 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.80 |
| CHEMBL1081031 | — | — | 1 | 7.66 |
| CHEMBL1242981 | — | — | 1 | 7.57 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | — | 1 | 7.30 |
| CHEMBL74926 | PHENSERINE | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081032 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL362444 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5090683 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1081031 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1242981 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL74926 | PHENSERINE | IC50 | = | 1560.0 | nM | 5.81 |