Assay Detail
Binding
CHEMBL5043885
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Inhibition of human recombinant HDAC3 using Boc-Lys(acetyl)-AMC substrate incubated for 2 hrs by fluorescence based assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 9.08 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4597954 | — | — | 1 | 9.55 |
| CHEMBL5093099 | — | — | 1 | 9.55 |
| CHEMBL5078985 | — | — | 1 | 9.42 |
| CHEMBL5083249 | — | — | 1 | 9.36 |
| CHEMBL5086141 | — | — | 1 | 9.29 |
| CHEMBL5087431 | — | — | 1 | 9.26 |
| CHEMBL5080511 | — | — | 1 | 9.24 |
| CHEMBL5083475 | — | — | 1 | 9.21 |
| CHEMBL5089712 | — | — | 1 | 9.21 |
| CHEMBL5087971 | — | — | 1 | 9.18 |
| CHEMBL5093836 | — | — | 1 | 9.08 |
| CHEMBL5089744 | — | — | 1 | 9.07 |
| CHEMBL5073909 | — | — | 1 | 9.05 |
| CHEMBL5084347 | — | — | 1 | 9.05 |
| CHEMBL4526892 | — | — | 1 | 9.02 |
| CHEMBL5075150 | — | — | 1 | 8.99 |
| CHEMBL5076715 | — | — | 1 | 8.88 |
| CHEMBL5084847 | — | — | 1 | 8.88 |
| CHEMBL5081353 | — | — | 1 | 8.84 |
| CHEMBL5086924 | — | — | 1 | 8.83 |
| CHEMBL5075425 | — | — | 1 | 8.81 |
| CHEMBL5089258 | — | — | 1 | 8.79 |
| CHEMBL5073024 | — | — | 1 | 8.75 |
| CHEMBL5074837 | — | — | 1 | 8.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4597954 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL5093099 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL5078985 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL5083249 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL5086141 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL5087431 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL5080511 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL5083475 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL5089712 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL5087971 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL5093836 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL5089744 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL5073909 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5084347 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL4526892 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL5075150 | — | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL5076715 | — | IC50 | = | 1.31 | nM | 8.88 |
| CHEMBL5084847 | — | IC50 | = | 1.31 | nM | 8.88 |
| CHEMBL5081353 | — | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL5086924 | — | IC50 | = | 1.48 | nM | 8.83 |
| CHEMBL5075425 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL5089258 | — | IC50 | = | 1.61 | nM | 8.79 |
| CHEMBL5073024 | — | IC50 | = | 1.79 | nM | 8.75 |
| CHEMBL5074837 | — | IC50 | = | 2.03 | nM | 8.69 |