Assay Detail
Binding
CHEMBL5044553
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Inhibition of BRD4 D1 (unknown origin) by competitive fluorescence anisotropy assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.17 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5086716 | — | — | 1 | 7.00 |
| CHEMBL5089270 | — | — | 1 | 6.96 |
| CHEMBL5090760 | — | — | 1 | 6.96 |
| CHEMBL5088918 | — | — | 1 | 6.72 |
| CHEMBL5079869 | — | — | 1 | 6.70 |
| CHEMBL5081513 | — | — | 1 | 6.70 |
| CHEMBL5082969 | — | — | 1 | 6.58 |
| CHEMBL5087306 | — | — | 1 | 6.57 |
| CHEMBL5084290 | — | — | 1 | 6.52 |
| CHEMBL5085763 | — | — | 1 | 6.51 |
| CHEMBL5084552 | — | — | 1 | 6.44 |
| CHEMBL5091410 | — | — | 1 | 6.37 |
| CHEMBL5079566 | — | — | 1 | 6.36 |
| CHEMBL5080722 | — | — | 1 | 6.30 |
| CHEMBL5085543 | — | — | 1 | 6.21 |
| CHEMBL5092030 | — | — | 1 | 6.06 |
| CHEMBL5075239 | — | — | 1 | 5.96 |
| CHEMBL5092296 | — | — | 1 | 5.96 |
| CHEMBL5088397 | — | — | 1 | 5.72 |
| CHEMBL5085815 | — | — | 1 | 5.62 |
| CHEMBL5088844 | — | — | 1 | 5.62 |
| CHEMBL5079170 | — | — | 1 | 5.57 |
| CHEMBL5078369 | — | — | 1 | 5.52 |
| CHEMBL5089289 | — | — | 1 | 5.42 |
| CHEMBL5085512 | — | — | 1 | 5.03 |
| CHEMBL4521096 | — | — | 1 | 4.96 |
| CHEMBL5085224 | — | — | 1 | - |
| CHEMBL5078890 | — | — | 1 | - |
| CHEMBL5087797 | — | — | 1 | - |
| CHEMBL5075050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5086716 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5089270 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5090760 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5088918 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5079869 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5081513 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5082969 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5087306 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5084290 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5085763 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5084552 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5091410 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5079566 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5080722 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5085543 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5092030 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5075239 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5092296 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5088397 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5085815 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5088844 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5079170 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5078369 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5089289 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5085512 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4521096 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5085224 | — | IC50 | < | 92.0 | nM | - |
| CHEMBL5078890 | — | IC50 | < | 92.0 | nM | - |
| CHEMBL5087797 | — | IC50 | < | 92.0 | nM | - |
| CHEMBL5075050 | — | IC50 | < | 92.0 | nM | - |
| CHEMBL5085236 | — | IC50 | < | 92.0 | nM | - |
| CHEMBL5082732 | — | IC50 | < | 92.0 | nM | - |
| CHEMBL1957266 | — | IC50 | < | 92.0 | nM | - |