Assay Detail
Binding
CHEMBL5044556
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Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.87 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4521096 | — | — | 1 | 9.33 |
| CHEMBL417255 | — | — | 1 | 7.39 |
| CHEMBL5087797 | — | — | 1 | 7.01 |
| CHEMBL5085236 | — | — | 1 | 7.00 |
| CHEMBL5085763 | — | — | 1 | 6.58 |
| CHEMBL5082732 | — | — | 1 | 6.11 |
| CHEMBL5088918 | — | — | 1 | 5.82 |
| CHEMBL5080097 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4521096 | — | Kd | = | 0.47 | nM | 9.33 |
| CHEMBL417255 | — | Kd | = | 41.0 | nM | 7.39 |
| CHEMBL5087797 | — | Kd | = | 98.0 | nM | 7.01 |
| CHEMBL5085236 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL5085763 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL5082732 | — | Kd | = | 780.0 | nM | 6.11 |
| CHEMBL5088918 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL5080097 | — | Kd | = | 1900.0 | nM | 5.72 |