Assay Detail
Functional
CHEMBL5044666
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.75 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5093832 | — | — | 1 | 6.29 |
| CHEMBL5082644 | — | — | 1 | 6.04 |
| CHEMBL5080669 | — | — | 1 | 6.03 |
| CHEMBL5092352 | — | — | 1 | 5.93 |
| CHEMBL511749 | — | — | 1 | 5.83 |
| CHEMBL5070026 | — | — | 1 | 5.78 |
| CHEMBL5077674 | — | — | 1 | 5.75 |
| CHEMBL5079482 | — | — | 1 | 5.74 |
| CHEMBL5085871 | — | — | 1 | 5.66 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.62 |
| CHEMBL5093602 | — | — | 1 | 5.54 |
| CHEMBL5069541 | — | — | 1 | 5.49 |
| CHEMBL5079646 | — | — | 1 | 5.41 |
| CHEMBL5076163 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5093832 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5082644 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5080669 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5092352 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL511749 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5070026 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5077674 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5079482 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL5085871 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL5093602 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL5069541 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL5079646 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL5076163 | — | IC50 | = | 4120.0 | nM | 5.38 |