Assay Detail
Binding
CHEMBL5044758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARalpha (unknown origin)
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 47 | 7.00 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21241 | GW7647 | — | 1 | 8.85 |
| CHEMBL5082865 | — | — | 1 | 8.17 |
| CHEMBL5084377 | — | — | 1 | 8.15 |
| CHEMBL5081996 | — | — | 1 | 8.14 |
| CHEMBL5075917 | — | — | 1 | 8.12 |
| CHEMBL5085927 | — | — | 1 | 8.12 |
| CHEMBL5075951 | — | — | 1 | 8.07 |
| CHEMBL5087638 | — | — | 1 | 8.03 |
| CHEMBL5072619 | — | — | 1 | 7.85 |
| CHEMBL5076090 | — | — | 1 | 7.64 |
| CHEMBL5078556 | — | — | 1 | 7.59 |
| CHEMBL5084826 | — | — | 1 | 7.49 |
| CHEMBL5094105 | — | — | 1 | 7.45 |
| CHEMBL5089010 | — | — | 1 | 7.35 |
| CHEMBL5077367 | — | — | 1 | 7.23 |
| CHEMBL5081988 | — | — | 1 | 7.21 |
| CHEMBL4470753 | — | — | 1 | 7.19 |
| CHEMBL5089733 | — | — | 1 | 7.14 |
| CHEMBL5085903 | — | — | 1 | 7.10 |
| CHEMBL5082783 | — | — | 1 | 7.07 |
| CHEMBL5090142 | — | — | 1 | 6.99 |
| CHEMBL5094903 | — | — | 1 | 6.87 |
| CHEMBL5092961 | — | — | 1 | 6.84 |
| CHEMBL5079871 | — | — | 1 | 6.79 |
| CHEMBL5085496 | — | — | 1 | 6.78 |
| CHEMBL5087115 | — | — | 1 | 6.76 |
| CHEMBL5084019 | — | — | 1 | 6.75 |
| CHEMBL5086358 | — | — | 1 | 6.67 |
| CHEMBL5088968 | — | — | 1 | 6.66 |
| CHEMBL5084763 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21241 | GW7647 | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5082865 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL5084377 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5081996 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5075917 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5085927 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5075951 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL5087638 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5072619 | — | EC50 | = | 14.2 | nM | 7.85 |
| CHEMBL5076090 | — | EC50 | = | 23.1 | nM | 7.64 |
| CHEMBL5078556 | — | EC50 | = | 25.9 | nM | 7.59 |
| CHEMBL5084826 | — | EC50 | = | 32.6 | nM | 7.49 |
| CHEMBL5094105 | — | EC50 | = | 35.3 | nM | 7.45 |
| CHEMBL5089010 | — | EC50 | = | 44.4 | nM | 7.35 |
| CHEMBL5077367 | — | EC50 | = | 59.1 | nM | 7.23 |
| CHEMBL5081988 | — | EC50 | = | 62.2 | nM | 7.21 |
| CHEMBL4470753 | — | EC50 | = | 65.1 | nM | 7.19 |
| CHEMBL5089733 | — | EC50 | = | 72.2 | nM | 7.14 |
| CHEMBL5085903 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5082783 | — | EC50 | = | 85.9 | nM | 7.07 |
| CHEMBL5090142 | — | EC50 | = | 102.7 | nM | 6.99 |
| CHEMBL5094903 | — | EC50 | = | 133.8 | nM | 6.87 |
| CHEMBL5092961 | — | EC50 | = | 144.1 | nM | 6.84 |
| CHEMBL5079871 | — | EC50 | = | 162.4 | nM | 6.79 |
| CHEMBL5085496 | — | EC50 | = | 166.6 | nM | 6.78 |
| CHEMBL5087115 | — | EC50 | = | 172.4 | nM | 6.76 |
| CHEMBL5084019 | — | EC50 | = | 179.8 | nM | 6.75 |
| CHEMBL5086358 | — | EC50 | = | 214.6 | nM | 6.67 |
| CHEMBL5088968 | — | EC50 | = | 219.7 | nM | 6.66 |
| CHEMBL5084763 | — | EC50 | = | 272.5 | nM | 6.57 |
| CHEMBL5081430 | — | EC50 | = | 288.8 | nM | 6.54 |
| CHEMBL5076063 | — | EC50 | = | 341.0 | nM | 6.47 |
| CHEMBL5087349 | — | EC50 | = | 351.2 | nM | 6.45 |
| CHEMBL5077842 | — | EC50 | = | 382.4 | nM | 6.42 |
| CHEMBL5070178 | — | EC50 | = | 386.5 | nM | 6.41 |
| CHEMBL5075465 | — | EC50 | = | 394.4 | nM | 6.40 |
| CHEMBL5076583 | — | EC50 | = | 418.9 | nM | 6.38 |
| CHEMBL5091032 | — | EC50 | = | 497.5 | nM | 6.30 |
| CHEMBL5089520 | — | EC50 | = | 644.6 | nM | 6.19 |
| CHEMBL3707395 | ELAFIBRANOR | EC50 | = | 820.3 | nM | 6.09 |
| CHEMBL5087157 | — | EC50 | = | 1027.0 | nM | 5.99 |
| CHEMBL5088489 | — | EC50 | = | 1866.0 | nM | 5.73 |
| CHEMBL4091374 | LANIFIBRANOR | EC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL5080431 | — | EC50 | = | 4572.0 | nM | 5.34 |
| CHEMBL5084631 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5073521 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5077836 | — | EC50 | > | 5000.0 | nM | - |