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Compound Detail

CHEMBL5085927

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Cc1cc(Cn2ncn(-c3ccc(OC(F)(F)F)cc3)c2=O)cc(Cl)c1OC(C)(C)C(=O)O

Basic Information

ChEMBL ID CHEMBL5085927
Phase Preclinical
Structure Type MOL
InChI Key HYKCTJDLYFUROT-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

485.9
MW (Da)
4.18
ALogP
7
HBA
1
HBD
95.6
PSA (Ų)
0.54
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H19ClF3N3O5
MW 485.85
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -1.08

Activity Summary

EC50 2 meas. best 8.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor alpha
CHEMBL239
EC50 8.12 8.12 7.6 1
Peroxisome proliferator-activated receptor delta
CHEMBL3979
EC50 7.54 7.54 28.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35060744 10.1021/acs.jmedchem.1c02002 Peroxisome proliferator-activated receptor alpha 2
35060744 10.1021/acs.jmedchem.1c02002 Peroxisome proliferator-activated receptor delta 2
35060744 10.1021/acs.jmedchem.1c02002 Peroxisome proliferator-activated receptor gamma 1

Data from ChEMBL 36 via Core Engine