Assay Detail
Binding
CHEMBL5044759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARdelta (unknown origin)
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 47 | 6.96 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38943 | GW501516 | 2.0 | 1 | 9.30 |
| CHEMBL5081996 | — | — | 1 | 8.85 |
| CHEMBL5078556 | — | — | 1 | 8.77 |
| CHEMBL5094105 | — | — | 1 | 8.25 |
| CHEMBL5084377 | — | — | 1 | 8.08 |
| CHEMBL5075951 | — | — | 1 | 7.83 |
| CHEMBL5081988 | — | — | 1 | 7.67 |
| CHEMBL4470753 | — | — | 1 | 7.62 |
| CHEMBL5085927 | — | — | 1 | 7.54 |
| CHEMBL5085903 | — | — | 1 | 7.42 |
| CHEMBL5089733 | — | — | 1 | 7.41 |
| CHEMBL5077367 | — | — | 1 | 7.38 |
| CHEMBL5089010 | — | — | 1 | 7.38 |
| CHEMBL5085496 | — | — | 1 | 7.33 |
| CHEMBL5082783 | — | — | 1 | 7.25 |
| CHEMBL5072619 | — | — | 1 | 7.17 |
| CHEMBL5070178 | — | — | 1 | 7.09 |
| CHEMBL5076090 | — | — | 1 | 7.06 |
| CHEMBL5084763 | — | — | 1 | 7.04 |
| CHEMBL5077842 | — | — | 1 | 6.91 |
| CHEMBL5090142 | — | — | 1 | 6.88 |
| CHEMBL5087638 | — | — | 1 | 6.87 |
| CHEMBL5075917 | — | — | 1 | 6.76 |
| CHEMBL5081430 | — | — | 1 | 6.74 |
| CHEMBL5094903 | — | — | 1 | 6.67 |
| CHEMBL5082865 | — | — | 1 | 6.65 |
| CHEMBL5079871 | — | — | 1 | 6.64 |
| CHEMBL5084019 | — | — | 1 | 6.61 |
| CHEMBL5092961 | — | — | 1 | 6.56 |
| CHEMBL5086358 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38943 | GW501516 | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5081996 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5078556 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5094105 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL5084377 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL5075951 | — | EC50 | = | 14.7 | nM | 7.83 |
| CHEMBL5081988 | — | EC50 | = | 21.6 | nM | 7.67 |
| CHEMBL4470753 | — | EC50 | = | 24.2 | nM | 7.62 |
| CHEMBL5085927 | — | EC50 | = | 28.5 | nM | 7.54 |
| CHEMBL5085903 | — | EC50 | = | 38.1 | nM | 7.42 |
| CHEMBL5089733 | — | EC50 | = | 38.6 | nM | 7.41 |
| CHEMBL5077367 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5089010 | — | EC50 | = | 42.1 | nM | 7.38 |
| CHEMBL5085496 | — | EC50 | = | 46.6 | nM | 7.33 |
| CHEMBL5082783 | — | EC50 | = | 55.6 | nM | 7.25 |
| CHEMBL5072619 | — | EC50 | = | 66.9 | nM | 7.17 |
| CHEMBL5070178 | — | EC50 | = | 81.3 | nM | 7.09 |
| CHEMBL5076090 | — | EC50 | = | 87.1 | nM | 7.06 |
| CHEMBL5084763 | — | EC50 | = | 90.7 | nM | 7.04 |
| CHEMBL5077842 | — | EC50 | = | 123.8 | nM | 6.91 |
| CHEMBL5090142 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL5087638 | — | EC50 | = | 134.6 | nM | 6.87 |
| CHEMBL5075917 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL5081430 | — | EC50 | = | 181.3 | nM | 6.74 |
| CHEMBL5094903 | — | EC50 | = | 211.6 | nM | 6.67 |
| CHEMBL5082865 | — | EC50 | = | 225.1 | nM | 6.65 |
| CHEMBL5079871 | — | EC50 | = | 229.3 | nM | 6.64 |
| CHEMBL5084019 | — | EC50 | = | 247.7 | nM | 6.61 |
| CHEMBL5092961 | — | EC50 | = | 278.0 | nM | 6.56 |
| CHEMBL5086358 | — | EC50 | = | 278.1 | nM | 6.56 |
| CHEMBL5087115 | — | EC50 | = | 323.3 | nM | 6.49 |
| CHEMBL5089520 | — | EC50 | = | 388.8 | nM | 6.41 |
| CHEMBL5084826 | — | EC50 | = | 480.7 | nM | 6.32 |
| CHEMBL5076583 | — | EC50 | = | 585.7 | nM | 6.23 |
| CHEMBL5076063 | — | EC50 | = | 619.6 | nM | 6.21 |
| CHEMBL5087157 | — | EC50 | = | 647.0 | nM | 6.19 |
| CHEMBL5075465 | — | EC50 | = | 663.7 | nM | 6.18 |
| CHEMBL3707395 | ELAFIBRANOR | EC50 | = | 842.9 | nM | 6.07 |
| CHEMBL5088968 | — | EC50 | = | 914.1 | nM | 6.04 |
| CHEMBL5087349 | — | EC50 | = | 1367.0 | nM | 5.86 |
| CHEMBL5088489 | — | EC50 | = | 1519.0 | nM | 5.82 |
| CHEMBL5091032 | — | EC50 | = | 1675.0 | nM | 5.78 |
| CHEMBL4091374 | LANIFIBRANOR | EC50 | = | 2962.0 | nM | 5.53 |
| CHEMBL5084631 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5073521 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5080431 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5077836 | — | EC50 | > | 5000.0 | nM | - |