Assay Detail
Binding
CHEMBL5044760
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARgamma (unknown origin)
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 47 | 5.76 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.77 |
| CHEMBL4091374 | LANIFIBRANOR | 3.0 | 1 | 6.25 |
| CHEMBL5081996 | — | — | 1 | 6.09 |
| CHEMBL5087157 | — | — | 1 | 6.06 |
| CHEMBL5084019 | — | — | 1 | 6.02 |
| CHEMBL5072619 | — | — | 1 | 5.93 |
| CHEMBL5084377 | — | — | 1 | 5.88 |
| CHEMBL5078556 | — | — | 1 | 5.84 |
| CHEMBL5077842 | — | — | 1 | 5.84 |
| CHEMBL5089520 | — | — | 1 | 5.82 |
| CHEMBL5084763 | — | — | 1 | 5.78 |
| CHEMBL5094105 | — | — | 1 | 5.78 |
| CHEMBL5087638 | — | — | 1 | 5.75 |
| CHEMBL5075917 | — | — | 1 | 5.75 |
| CHEMBL5070178 | — | — | 1 | 5.75 |
| CHEMBL5075951 | — | — | 1 | 5.75 |
| CHEMBL5090142 | — | — | 1 | 5.75 |
| CHEMBL5081988 | — | — | 1 | 5.75 |
| CHEMBL5085496 | — | — | 1 | 5.74 |
| CHEMBL3707395 | ELAFIBRANOR | 4.0 | 1 | 5.73 |
| CHEMBL5076063 | — | — | 1 | 5.72 |
| CHEMBL5092961 | — | — | 1 | 5.70 |
| CHEMBL5085903 | — | — | 1 | 5.69 |
| CHEMBL5077367 | — | — | 1 | 5.66 |
| CHEMBL5089733 | — | — | 1 | 5.60 |
| CHEMBL4470753 | — | — | 1 | 5.56 |
| CHEMBL5079871 | — | — | 1 | 5.56 |
| CHEMBL5081430 | — | — | 1 | 5.55 |
| CHEMBL5089010 | — | — | 1 | 5.51 |
| CHEMBL5073521 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4091374 | LANIFIBRANOR | EC50 | = | 558.9 | nM | 6.25 |
| CHEMBL5081996 | — | EC50 | = | 812.2 | nM | 6.09 |
| CHEMBL5087157 | — | EC50 | = | 865.0 | nM | 6.06 |
| CHEMBL5084019 | — | EC50 | = | 954.7 | nM | 6.02 |
| CHEMBL5072619 | — | EC50 | = | 1180.3 | nM | 5.93 |
| CHEMBL5084377 | — | EC50 | = | 1316.1 | nM | 5.88 |
| CHEMBL5078556 | — | EC50 | = | 1428.5 | nM | 5.84 |
| CHEMBL5077842 | — | EC50 | = | 1447.0 | nM | 5.84 |
| CHEMBL5089520 | — | EC50 | = | 1511.0 | nM | 5.82 |
| CHEMBL5084763 | — | EC50 | = | 1654.0 | nM | 5.78 |
| CHEMBL5094105 | — | EC50 | = | 1678.5 | nM | 5.78 |
| CHEMBL5090142 | — | EC50 | = | 1795.5 | nM | 5.75 |
| CHEMBL5075917 | — | EC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL5070178 | — | EC50 | = | 1775.9 | nM | 5.75 |
| CHEMBL5087638 | — | EC50 | = | 1784.2 | nM | 5.75 |
| CHEMBL5075951 | — | EC50 | = | 1794.8 | nM | 5.75 |
| CHEMBL5081988 | — | EC50 | = | 1778.8 | nM | 5.75 |
| CHEMBL5085496 | — | EC50 | = | 1831.6 | nM | 5.74 |
| CHEMBL3707395 | ELAFIBRANOR | EC50 | = | 1843.8 | nM | 5.73 |
| CHEMBL5076063 | — | EC50 | = | 1885.0 | nM | 5.72 |
| CHEMBL5092961 | — | EC50 | = | 2019.7 | nM | 5.70 |
| CHEMBL5085903 | — | EC50 | = | 2023.7 | nM | 5.69 |
| CHEMBL5077367 | — | EC50 | = | 2190.3 | nM | 5.66 |
| CHEMBL5089733 | — | EC50 | = | 2526.3 | nM | 5.60 |
| CHEMBL4470753 | — | EC50 | = | 2753.0 | nM | 5.56 |
| CHEMBL5079871 | — | EC50 | = | 2779.0 | nM | 5.56 |
| CHEMBL5081430 | — | EC50 | = | 2845.8 | nM | 5.55 |
| CHEMBL5089010 | — | EC50 | = | 3089.9 | nM | 5.51 |
| CHEMBL5073521 | — | EC50 | = | 3789.5 | nM | 5.42 |
| CHEMBL5086358 | — | EC50 | = | 4679.0 | nM | 5.33 |
| CHEMBL5076090 | — | EC50 | = | 4906.2 | nM | 5.31 |
| CHEMBL5087115 | — | EC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL5084631 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5094903 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5082783 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5080431 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5077836 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5084826 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5088489 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5075465 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5076583 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5091032 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5088968 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5087349 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5082865 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5085927 | — | EC50 | > | 5000.0 | nM | - |