Assay Detail
Binding
CHEMBL5044776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse PPARgamma in Cos7 cells transfected with pBIND and pGL4.35 Gal4 UAS Luc reporter plasmid by measuring luciferase activity incubated for 16 hrs by luciferase reporter gene assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | COS7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL2459) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.99 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5084377 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5084377 | — | EC50 | = | 1013.0 | nM | 5.99 |