Assay Detail
Binding
CHEMBL5045446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Candida albicans Fructose-1,6-Bisphosphate Aldolase C157S mutant transfected in Escherichia coli BL21 (DE3) incubated for 3 mins in presence of NADH by spectrophotometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of <i>Candidiasis</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.35 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 7.51 |
| CHEMBL5090832 | — | — | 1 | 6.64 |
| CHEMBL5075467 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5090832 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL5075467 | — | IC50 | = | 12500.0 | nM | 4.90 |