Assay Detail
Binding
CHEMBL5045654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Alexafluor 647-JQ1 from GST-BRD4 BD1 BD2 (44 to 460 residues) (unknown origin) incubated for 60 mins by fluorescence polarization assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.77 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083025 | — | — | 1 | 5.10 |
| CHEMBL5090538 | — | — | 1 | 5.10 |
| CHEMBL5083653 | — | — | 1 | 4.80 |
| CHEMBL5079885 | — | — | 1 | 4.70 |
| CHEMBL5087319 | — | — | 1 | 4.60 |
| CHEMBL5084768 | — | — | 1 | 4.60 |
| CHEMBL5074983 | — | — | 1 | 4.50 |
| CHEMBL5090410 | — | — | 1 | - |
| CHEMBL5074753 | — | — | 1 | - |
| CHEMBL5083337 | — | — | 1 | - |
| CHEMBL5084439 | — | — | 1 | - |
| CHEMBL5087156 | — | — | 1 | - |
| CHEMBL5075463 | — | — | 1 | - |
| CHEMBL5093167 | — | — | 1 | - |
| CHEMBL5086260 | — | — | 1 | - |
| CHEMBL5092181 | — | — | 1 | - |
| CHEMBL5077167 | — | — | 1 | - |
| CHEMBL5086059 | — | — | 1 | - |
| CHEMBL5093862 | — | — | 1 | - |
| CHEMBL5090369 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083025 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL5090538 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL5083653 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL5079885 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL5087319 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL5084768 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL5074983 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL5090410 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5074753 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5083337 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5084439 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5087156 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5075463 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5093167 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5086260 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5092181 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5077167 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5086059 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5093862 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL5090369 | — | IC50 | > | 31622.78 | nM | - |