Assay Detail
Functional
CHEMBL5045720
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Antiproliferative activity against human WI-38 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WI-38 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.84 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075192 | — | — | 1 | 5.89 |
| CHEMBL5089164 | — | — | 1 | 5.79 |
| CHEMBL5092606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075192 | — | IC50 | = | 1294.0 | nM | 5.89 |
| CHEMBL5089164 | — | IC50 | = | 1618.67 | nM | 5.79 |
| CHEMBL5092606 | — | IC50 | > | 10.0 | nM | - |