Assay Detail
Functional
CHEMBL5045752
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Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835V mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.08 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075192 | — | — | 1 | 9.51 |
| CHEMBL5089164 | — | — | 1 | 8.89 |
| CHEMBL5092606 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075192 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL5089164 | — | IC50 | = | 1.29 | nM | 8.89 |
| CHEMBL5092606 | — | IC50 | = | 1.41 | nM | 8.85 |