Assay Detail
Binding
CHEMBL5045929
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by q-PCR based bromoscan assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcription initiation factor TFIID subunit 1 (CHEMBL3217390) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.99 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 6.76 |
| CHEMBL2325697 | — | — | 1 | 5.21 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285417 | CERALASERTIB | Kd | = | 175.0 | nM | 6.76 |
| CHEMBL2325697 | — | Kd | = | 6167.0 | nM | 5.21 |
| CHEMBL513909 | BI-2536 | Kd | - | — | - |