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Assay Detail

CHEMBL5045933

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Binding
Binding affinity to TAF1 BD 2 (unknown origin) assessed as dissociation constant
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Transcription initiation factor TFIID subunit 1 (CHEMBL3217390)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.
Karim RM, Yang L, Chen L, Bikowitz MJ, Lu J, Grassie D, Shultz ZP, Lopchuk JM, Chen J, Schönbrunn E.
J Med Chem (2022) 65 : 4182 -4200
PubMed 35191694 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 7.77 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3133807 1 7.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3133807 Kd = 17.0 nM 7.77