Assay Detail
Functional
CHEMBL5046020
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by cell-titer glo assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.22 | 5.37 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5073757 | — | — | 1 | 5.37 |
| CHEMBL5084955 | — | — | 1 | 5.28 |
| CHEMBL5077287 | — | — | 1 | 5.14 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 5.08 |
| CHEMBL5077743 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5073757 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5084955 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5077287 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL235191 | TACEDINALINE | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5077743 | — | Activity | - | — | - |