Assay Detail
Toxicity
CHEMBL5046461
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Cytotoxicity against human BJ cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | BJ |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of New Imidazo[2,1-<i>b</i>]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising <i>In Vitro</i> and <i>In Vivo</i> Anti-melanoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.27 | 4.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081210 | — | — | 1 | 4.37 |
| CHEMBL5086749 | — | — | 1 | 4.34 |
| CHEMBL5083036 | — | — | 1 | 4.30 |
| CHEMBL5087577 | — | — | 1 | 4.30 |
| CHEMBL5075200 | — | — | 1 | 4.25 |
| CHEMBL5073858 | — | — | 1 | 4.21 |
| CHEMBL5079413 | — | — | 1 | 4.12 |
| CHEMBL5077227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081210 | — | IC50 | = | 42320.0 | nM | 4.37 |
| CHEMBL5086749 | — | IC50 | = | 45220.0 | nM | 4.34 |
| CHEMBL5083036 | — | IC50 | = | 50620.0 | nM | 4.30 |
| CHEMBL5087577 | — | IC50 | = | 49560.0 | nM | 4.30 |
| CHEMBL5075200 | — | IC50 | = | 55640.0 | nM | 4.25 |
| CHEMBL5073858 | — | IC50 | = | 62360.0 | nM | 4.21 |
| CHEMBL5079413 | — | IC50 | = | 75640.0 | nM | 4.12 |
| CHEMBL5077227 | — | IC50 | = | 125650.0 | nM | - |