Assay Detail
Binding
CHEMBL5046582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TrkA (440 to end residues) using KKKSPGEYVNIEFG as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.62 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5093111 | — | — | 1 | 6.82 |
| CHEMBL5083125 | — | — | 1 | 6.80 |
| CHEMBL5079149 | — | — | 1 | 6.55 |
| CHEMBL5088682 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5093111 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5083125 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL5079149 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL5088682 | — | IC50 | = | 477.0 | nM | 6.32 |