Assay Detail
Binding
CHEMBL5046589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of tracer K5 from NLuc fused TBK1 (unknown origin) expressed in HEK293 cells by NanoBRET assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase TBK1 (CHEMBL5408) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.81 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5079920 | — | — | 1 | 6.49 |
| CHEMBL4446892 | — | — | 1 | 6.47 |
| CHEMBL5085430 | — | — | 1 | 6.47 |
| CHEMBL5093111 | — | — | 1 | 5.69 |
| CHEMBL3916849 | — | — | 1 | 5.63 |
| CHEMBL5090046 | — | — | 1 | 5.59 |
| CHEMBL5079601 | — | — | 1 | 5.57 |
| CHEMBL5079149 | — | — | 1 | 5.21 |
| CHEMBL5084750 | — | — | 1 | 5.13 |
| CHEMBL5086901 | — | — | 1 | - |
| CHEMBL5083125 | — | — | 1 | - |
| CHEMBL5088682 | — | — | 1 | - |
| CHEMBL5085698 | — | — | 1 | - |
| CHEMBL5089987 | — | — | 1 | - |
| CHEMBL5087433 | — | — | 1 | - |
| CHEMBL5075360 | — | — | 1 | - |
| CHEMBL5087006 | — | — | 1 | - |
| CHEMBL5091582 | — | — | 1 | - |
| CHEMBL5091688 | — | — | 1 | - |
| CHEMBL5072178 | — | — | 1 | - |
| CHEMBL5088930 | — | — | 1 | - |
| CHEMBL5076165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5079920 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL4446892 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL5085430 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL5093111 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL3916849 | — | IC50 | = | 2327.0 | nM | 5.63 |
| CHEMBL5090046 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5079601 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL5079149 | — | IC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL5084750 | — | IC50 | = | 7456.0 | nM | 5.13 |
| CHEMBL5086901 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5083125 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5088682 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5085698 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5089987 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5087433 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5075360 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5087006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5091582 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5091688 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5072178 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5088930 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5076165 | — | IC50 | > | 10000.0 | nM | - |