Assay Detail
Binding
CHEMBL5046593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AAK1 using peptide as substrate incubated for 120 mins in presence of [gamma-33ATP] by scintillation counting based radiometry assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.88 | 7.13 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5079149 | — | — | 2 | 7.13 |
| CHEMBL5083125 | — | — | 1 | 7.10 |
| CHEMBL5075360 | — | — | 1 | 6.41 |
| CHEMBL5079920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5079149 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5083125 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5075360 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5079920 | — | Inhibition | - | % | - | |
| CHEMBL5079149 | — | Inhibition | - | % | - |