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Assay Detail

CHEMBL5046618

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of full length recombinant human CSNK2A2 using RRRDDDSDDD a substrate incubated for 40 mins in presence of [gamma-33P-ATP] by radiometric scintillation assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Casein kinase II subunit alpha' (CHEMBL4070)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, Mathea S, Axtman AD.
J Med Chem (2022) 65 : 1313 -1328
PubMed 34333981 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.64 5.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5083125 1 5.64
CHEMBL5079149 1 5.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5083125 IC50 = 2304.0 nM 5.64
CHEMBL5079149 IC50 = 2269.0 nM 5.64