Assay Detail
Binding
CHEMBL5046623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NanoLuc-fused CSF1R (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.52 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.74 |
| CHEMBL5089987 | — | — | 1 | 5.30 |
| CHEMBL5072178 | — | — | 1 | - |
| CHEMBL5087006 | — | — | 1 | - |
| CHEMBL4446892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL5089987 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL5072178 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5087006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4446892 | — | IC50 | > | 10000.0 | nM | - |