Assay Detail
Functional
CHEMBL5046927
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Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Fluor cell viability assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.02 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089694 | — | — | 1 | 5.07 |
| CHEMBL5084156 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089694 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5084156 | — | IC50 | = | 10700.0 | nM | 4.97 |