Assay Detail
Toxicity
CHEMBL5046956
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Antiproliferative activity against human HEK293 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.01 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078072 | — | — | 1 | 5.55 |
| CHEMBL5077719 | — | — | 1 | 4.78 |
| CHEMBL5084275 | — | — | 1 | 4.70 |
| CHEMBL5073496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078072 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5077719 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL5084275 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5073496 | — | IC50 | > | 29000.0 | nM | - |