Assay Detail
Functional
CHEMBL5047396
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 57 | 7.17 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.10 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.48 |
| CHEMBL5087461 | — | — | 1 | 8.07 |
| CHEMBL5079986 | — | — | 1 | 8.05 |
| CHEMBL5089691 | — | — | 1 | 8.04 |
| CHEMBL5078724 | — | — | 1 | 7.75 |
| CHEMBL5080308 | — | — | 1 | 7.72 |
| CHEMBL5088919 | — | — | 1 | 7.66 |
| CHEMBL5080984 | — | — | 1 | 7.65 |
| CHEMBL5087351 | — | — | 1 | 7.65 |
| CHEMBL5087427 | — | — | 1 | 7.60 |
| CHEMBL5094829 | — | — | 1 | 7.58 |
| CHEMBL5085893 | — | — | 1 | 7.58 |
| CHEMBL5082360 | — | — | 1 | 7.55 |
| CHEMBL5092455 | — | — | 1 | 7.54 |
| CHEMBL5084736 | — | — | 1 | 7.54 |
| CHEMBL5077564 | — | — | 1 | 7.51 |
| CHEMBL5076629 | — | — | 1 | 7.44 |
| CHEMBL5088366 | — | — | 1 | 7.30 |
| CHEMBL5071558 | — | — | 1 | 7.24 |
| CHEMBL5082250 | — | — | 1 | 7.23 |
| CHEMBL5072039 | — | — | 1 | 7.18 |
| CHEMBL5082836 | — | — | 1 | 7.18 |
| CHEMBL5088143 | — | — | 1 | 7.18 |
| CHEMBL5093872 | — | — | 1 | 7.00 |
| CHEMBL5092918 | — | — | 1 | 6.97 |
| CHEMBL5088314 | — | — | 1 | 6.91 |
| CHEMBL5070726 | — | — | 1 | 6.91 |
| CHEMBL5089630 | — | — | 1 | 6.79 |
| CHEMBL5086036 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | EC50 | = | 0.79 | nM | 9.10 |
| CHEMBL56 | 8-OH-DPAT | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5087461 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL5079986 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5089691 | — | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL5078724 | — | EC50 | = | 17.92 | nM | 7.75 |
| CHEMBL5080308 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5088919 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5080984 | — | EC50 | = | 22.2 | nM | 7.65 |
| CHEMBL5087351 | — | EC50 | = | 22.4 | nM | 7.65 |
| CHEMBL5087427 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5094829 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5085893 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5082360 | — | EC50 | = | 28.3 | nM | 7.55 |
| CHEMBL5084736 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5092455 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5077564 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5076629 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5088366 | — | EC50 | = | 49.82 | nM | 7.30 |
| CHEMBL5071558 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5082250 | — | EC50 | = | 58.6 | nM | 7.23 |
| CHEMBL5072039 | — | EC50 | = | 65.24 | nM | 7.18 |
| CHEMBL5082836 | — | EC50 | = | 65.53 | nM | 7.18 |
| CHEMBL5088143 | — | EC50 | = | 66.6 | nM | 7.18 |
| CHEMBL5093872 | — | EC50 | = | 99.61 | nM | 7.00 |
| CHEMBL5092918 | — | EC50 | = | 106.6 | nM | 6.97 |
| CHEMBL5070726 | — | EC50 | = | 123.0 | nM | 6.91 |
| CHEMBL5088314 | — | EC50 | = | 123.78 | nM | 6.91 |
| CHEMBL5089630 | — | EC50 | = | 161.74 | nM | 6.79 |
| CHEMBL5086036 | — | EC50 | = | 160.5 | nM | 6.79 |
| CHEMBL5085109 | — | EC50 | = | 169.0 | nM | 6.77 |
| CHEMBL5082850 | — | EC50 | = | 175.6 | nM | 6.75 |
| CHEMBL5087922 | — | EC50 | = | 184.0 | nM | 6.74 |
| CHEMBL5074796 | — | EC50 | = | 202.54 | nM | 6.69 |
| CHEMBL5090651 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5088060 | — | EC50 | = | 278.8 | nM | 6.55 |
| CHEMBL5089999 | — | EC50 | = | 316.0 | nM | 6.50 |
| CHEMBL5086277 | — | EC50 | = | 323.46 | nM | 6.49 |
| CHEMBL5076277 | — | EC50 | = | 334.0 | nM | 6.48 |
| CHEMBL5087878 | — | EC50 | = | 405.0 | nM | 6.39 |
| CHEMBL5078629 | — | EC50 | = | 467.0 | nM | 6.33 |
| CHEMBL5069928 | — | EC50 | = | 521.0 | nM | 6.28 |
| CHEMBL5072034 | — | EC50 | = | 547.0 | nM | 6.26 |
| CHEMBL5071820 | — | EC50 | = | 619.88 | nM | 6.21 |
| CHEMBL5091978 | — | EC50 | = | 653.0 | nM | 6.18 |
| CHEMBL5080825 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5087923 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5075295 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5076406 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5086121 | — | EC50 | > | 1000.0 | nM | - |