Assay Detail
Binding
CHEMBL5047404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant AChE in human erythrocytes using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Erythrocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.69 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082250 | — | — | 1 | 9.24 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082250 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 7.39 | nM | 8.13 |