Assay Detail
Binding
CHEMBL5047434
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Inhibition of JAK1/JAK3 signalling in human PBMC assessed as inhibition of IL-2 stimulated IFN-gamma release incubated for 1 hr followed by IL-2 stimulation by MSD assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.89 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5077126 | — | — | 1 | 7.60 |
| CHEMBL5084542 | — | — | 1 | 7.60 |
| CHEMBL5086526 | — | — | 1 | 7.50 |
| CHEMBL5076189 | — | — | 1 | 7.40 |
| CHEMBL5076068 | — | — | 1 | 7.30 |
| CHEMBL5075556 | — | — | 1 | 7.20 |
| CHEMBL5078647 | — | — | 1 | 7.10 |
| CHEMBL5078141 | — | — | 1 | 7.10 |
| CHEMBL5076101 | — | — | 1 | 6.90 |
| CHEMBL5075673 | — | — | 1 | 6.90 |
| CHEMBL5075223 | — | — | 1 | 6.90 |
| CHEMBL5079248 | — | — | 1 | 6.80 |
| CHEMBL5085176 | — | — | 1 | 6.60 |
| CHEMBL5087255 | — | — | 1 | 6.60 |
| CHEMBL5094089 | — | — | 1 | 6.60 |
| CHEMBL5082928 | — | — | 1 | 6.50 |
| CHEMBL5084340 | — | — | 1 | 6.40 |
| CHEMBL5074310 | — | — | 1 | 6.30 |
| CHEMBL5084913 | — | — | 1 | 6.30 |
| CHEMBL5077653 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5077126 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL5084542 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL5086526 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL5076189 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5076068 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5075556 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5078647 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5078141 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5076101 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5075673 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5075223 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5079248 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL5085176 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5087255 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5094089 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5082928 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL5084340 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5074310 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL5084913 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL5077653 | — | IC50 | = | 630.96 | nM | 6.20 |