Assay Detail
Binding
CHEMBL5047787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin) using U-Light-4E-BP1 peptide as a substrate in presence of ATP incubated for 45 mins by Lance ultra assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.51 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5071085 | — | — | 1 | 9.05 |
| CHEMBL5080996 | — | — | 1 | 9.00 |
| CHEMBL5085872 | — | — | 1 | 8.92 |
| CHEMBL5074018 | — | — | 1 | 8.85 |
| CHEMBL5076528 | — | — | 1 | 8.72 |
| CHEMBL5083002 | — | — | 1 | 8.70 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 8.68 |
| CHEMBL5091543 | — | — | 1 | 8.68 |
| CHEMBL5093540 | — | — | 1 | 8.68 |
| CHEMBL5079231 | — | — | 1 | 8.66 |
| CHEMBL5084675 | — | — | 1 | 8.66 |
| CHEMBL5091789 | — | — | 1 | 8.64 |
| CHEMBL5079887 | — | — | 1 | 8.52 |
| CHEMBL5071429 | — | — | 1 | 8.51 |
| CHEMBL5071942 | — | — | 1 | 8.48 |
| CHEMBL5089561 | — | — | 1 | 8.48 |
| CHEMBL5094579 | — | — | 1 | 8.43 |
| CHEMBL5086369 | — | — | 1 | 8.38 |
| CHEMBL5079397 | — | — | 1 | 8.32 |
| CHEMBL5078347 | — | — | 1 | 8.24 |
| CHEMBL5070586 | — | — | 1 | 8.21 |
| CHEMBL5083425 | — | — | 1 | 8.14 |
| CHEMBL5085515 | — | — | 1 | 8.13 |
| CHEMBL5086413 | — | — | 1 | 8.12 |
| CHEMBL5073129 | — | — | 1 | 8.04 |
| CHEMBL5087372 | — | — | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5071085 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5080996 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5085872 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5074018 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5076528 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5083002 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5091543 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5093540 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5079231 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5084675 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5091789 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5079887 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5071429 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5071942 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5089561 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5094579 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5086369 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5079397 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5078347 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5070586 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5083425 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5085515 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5086413 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5073129 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5087372 | — | IC50 | = | 10.3 | nM | 7.99 |