Assay Detail
Binding
CHEMBL5047790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate in presence of ATP incubated for 60 mins by ADP-glo based luminescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.51 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091789 | — | — | 1 | 7.89 |
| CHEMBL5084675 | — | — | 1 | 7.79 |
| CHEMBL5093540 | — | — | 1 | 7.60 |
| CHEMBL5071942 | — | — | 1 | 7.56 |
| CHEMBL5079231 | — | — | 1 | 7.54 |
| CHEMBL5071085 | — | — | 1 | 7.36 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091789 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5084675 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL5093540 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5071942 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL5079231 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL5071085 | — | IC50 | = | 44.1 | nM | 7.36 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 156.0 | nM | 6.81 |