Assay Detail
Functional
CHEMBL5047795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.43 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 6.43 |
| CHEMBL5089561 | — | — | 1 | 6.16 |
| CHEMBL5071942 | — | — | 1 | 5.65 |
| CHEMBL5079397 | — | — | 1 | 5.65 |
| CHEMBL5091543 | — | — | 1 | 5.64 |
| CHEMBL5086413 | — | — | 1 | 5.50 |
| CHEMBL5080996 | — | — | 1 | 5.46 |
| CHEMBL5076528 | — | — | 1 | 5.42 |
| CHEMBL5074018 | — | — | 1 | 5.31 |
| CHEMBL5094579 | — | — | 1 | 5.15 |
| CHEMBL5085515 | — | — | 1 | 5.10 |
| CHEMBL5086369 | — | — | 1 | 5.04 |
| CHEMBL5070586 | — | — | 1 | 5.03 |
| CHEMBL5091789 | — | — | 1 | 4.98 |
| CHEMBL5083002 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5089561 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5071942 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL5079397 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL5091543 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL5086413 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL5080996 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5076528 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL5074018 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL5094579 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL5085515 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL5086369 | — | IC50 | = | 9030.0 | nM | 5.04 |
| CHEMBL5070586 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL5091789 | — | IC50 | = | 10440.0 | nM | 4.98 |
| CHEMBL5083002 | — | IC50 | = | 10500.0 | nM | 4.98 |