Assay Detail
Functional
CHEMBL5047796
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.50 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091543 | — | — | 1 | 6.89 |
| CHEMBL5079397 | — | — | 1 | 6.70 |
| CHEMBL5093540 | — | — | 1 | 6.34 |
| CHEMBL5076528 | — | — | 1 | 6.29 |
| CHEMBL5085872 | — | — | 1 | 6.27 |
| CHEMBL5080996 | — | — | 1 | 5.99 |
| CHEMBL5084675 | — | — | 1 | 5.50 |
| CHEMBL5089561 | — | — | 1 | 5.05 |
| CHEMBL5086369 | — | — | 1 | 4.98 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 4.83 |
| CHEMBL5071942 | — | — | 1 | 4.82 |
| CHEMBL5079887 | — | — | 1 | 4.78 |
| CHEMBL5086413 | — | — | 1 | 4.75 |
| CHEMBL5071429 | — | — | 1 | 4.73 |
| CHEMBL5085515 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091543 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5079397 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5093540 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5076528 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5085872 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5080996 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5084675 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL5089561 | — | IC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL5086369 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 14760.0 | nM | 4.83 |
| CHEMBL5071942 | — | IC50 | = | 15140.0 | nM | 4.82 |
| CHEMBL5079887 | — | IC50 | = | 16580.0 | nM | 4.78 |
| CHEMBL5086413 | — | IC50 | = | 17660.0 | nM | 4.75 |
| CHEMBL5071429 | — | IC50 | = | 18740.0 | nM | 4.73 |
| CHEMBL5085515 | — | IC50 | = | 24150.0 | nM | 4.62 |