Assay Detail
Functional
CHEMBL5048125
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Cytotoxicity against human SH-SY5Y cells using best fit nonlinear regression analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.53 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285275 | — | — | 1 | 5.67 |
| CHEMBL1801036 | CYCLOVIOLACIN O13 | — | 1 | 5.67 |
| CHEMBL5090055 | — | — | 1 | 5.54 |
| CHEMBL4211294 | — | — | 1 | 5.25 |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285275 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL1801036 | CYCLOVIOLACIN O13 | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL5090055 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL4211294 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | = | 393000.0 | nM | - |