Assay Detail

CHEMBL5048128

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Functional

Cytotoxicity against human U-87 MG cells by sulforhodamine B assay

ChEMBL ↗

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Target

U-87 MG (CHEMBL614247) ↗

Open DB target context

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U-87 MG (CHEMBL614247) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target U-87 MG

CHEMBL614247

Anchored from Assay target.

Protein identity U-87 MG

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	U-87MG ATCC
Confidence	1 — Organism
Curated By	Autocuration

Target

U-87 MG (CHEMBL614247) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide.

Gerlach SL, Dunlop RA, Metcalf JS, Banack SA, Cox PA.
J Nat Prod (2022) 85 : 34 -46
PubMed 35044783 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.92	6.35

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4285275	—	—	1	6.35
CHEMBL4211294	—	—	1	5.49

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4285275	—	IC50	=	450.0	nM	6.35
CHEMBL4211294	—	IC50	=	3210.0	nM	5.49