Assay Detail
Functional
CHEMBL5048531
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Cytotoxicity against human Hep 3B2.1-7 cells harboring FGF19/FGFR4 assessed as inhibition of cell growth
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.30 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5092315 | — | — | 1 | 6.98 |
| CHEMBL3908979 | FGF401 | 2.0 | 1 | 6.68 |
| CHEMBL4068896 | — | — | 1 | 6.26 |
| CHEMBL5070701 | — | — | 1 | 6.18 |
| CHEMBL5076701 | — | — | 1 | 5.87 |
| CHEMBL5069857 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5092315 | — | IC50 | = | 104.13 | nM | 6.98 |
| CHEMBL3908979 | FGF401 | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4068896 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5070701 | — | IC50 | = | 657.72 | nM | 6.18 |
| CHEMBL5076701 | — | IC50 | = | 1341.4 | nM | 5.87 |
| CHEMBL5069857 | — | IC50 | = | 1451.18 | nM | 5.84 |