Assay Detail
Functional
CHEMBL5048532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-453 cells harboring FGF19/FGFR4 assessed as inhibition of cell growth
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.28 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068896 | — | — | 1 | 6.92 |
| CHEMBL5092315 | — | — | 1 | 6.85 |
| CHEMBL5076701 | — | — | 1 | 6.33 |
| CHEMBL3908979 | FGF401 | 2.0 | 1 | 6.04 |
| CHEMBL5070701 | — | — | 1 | 5.88 |
| CHEMBL5069857 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068896 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5092315 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5076701 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL3908979 | FGF401 | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5070701 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL5069857 | — | IC50 | = | 2260.0 | nM | 5.65 |