Assay Detail
Binding
CHEMBL5048627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC3 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopy
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.08 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.05 |
| CHEMBL5086240 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5086240 | — | IC50 | = | 8000.0 | nM | 5.10 |