Assay Detail
Functional
CHEMBL5048800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 NL4-3(X4) pseudovirus infected in human TZM-bl cells assessed as reduction in viral infectivity measured after 48 hrs of postinfection by luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.02 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5077132 | — | — | 1 | 8.22 |
| CHEMBL5093818 | — | — | 1 | 8.15 |
| CHEMBL5083458 | — | — | 1 | 7.70 |
| CHEMBL5082142 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5077132 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5093818 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5083458 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5082142 | — | IC50 | > | 30.0 | nM | - |