Assay Detail
Binding
CHEMBL5048806
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Inhibition of M2 mAChR receptor (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.96 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3091687 | — | — | 1 | 5.12 |
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 1 | 5.12 |
| CHEMBL5070958 | — | — | 1 | 5.06 |
| CHEMBL5076569 | — | — | 1 | 4.52 |
| CHEMBL5093818 | — | — | 1 | - |
| CHEMBL5085511 | — | — | 1 | - |
| CHEMBL5077132 | — | — | 1 | - |
| CHEMBL5083458 | — | — | 1 | - |
| CHEMBL5081505 | — | — | 1 | - |
| CHEMBL5082142 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3091687 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL518924 | MAVORIXAFOR | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5070958 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5076569 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5093818 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5085511 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5077132 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5083458 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL5081505 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5082142 | — | IC50 | > | 30000.0 | nM | - |