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Assay Detail

CHEMBL5049167

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant AChE by Ellman's spectrophotometric assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.
Rullo M, Cipolloni M, Catto M, Colliva C, Miniero DV, Latronico T, de Candia M, Benicchi T, Linusson A, Giacchè N, Altomare CD, Pisani L.
J Med Chem (2022) 65 : 3962 -3977
PubMed 35195417 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.22 7.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL502 DONEPEZIL 4.0 1 7.64
CHEMBL3586771 1 6.92
CHEMBL5090153 1 6.48
CHEMBL4598256 1 6.42
CHEMBL5090504 1 6.34
CHEMBL5085674 1 6.33
CHEMBL5072382 1 6.32
CHEMBL5082824 1 6.26
CHEMBL5083613 1 6.25
CHEMBL4571763 1 6.08
CHEMBL4464759 1 6.05
CHEMBL5094348 1 6.04
CHEMBL4453856 1 5.96
CHEMBL5083014 1 5.92
CHEMBL5081663 1 5.92
CHEMBL5081574 1 5.92
CHEMBL5078658 1 5.82
CHEMBL5083737 1 5.77
CHEMBL5079544 1 5.66
CHEMBL396778 SAFINAMIDE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL502 DONEPEZIL IC50 = 23.0 nM 7.64
CHEMBL3586771 IC50 = 120.0 nM 6.92
CHEMBL5090153 IC50 = 330.0 nM 6.48
CHEMBL4598256 IC50 = 380.0 nM 6.42
CHEMBL5090504 IC50 = 460.0 nM 6.34
CHEMBL5085674 IC50 = 470.0 nM 6.33
CHEMBL5072382 IC50 = 480.0 nM 6.32
CHEMBL5082824 IC50 = 550.0 nM 6.26
CHEMBL5083613 IC50 = 560.0 nM 6.25
CHEMBL4571763 IC50 = 840.0 nM 6.08
CHEMBL4464759 IC50 = 890.0 nM 6.05
CHEMBL5094348 IC50 = 910.0 nM 6.04
CHEMBL4453856 IC50 = 1100.0 nM 5.96
CHEMBL5083014 IC50 = 1200.0 nM 5.92
CHEMBL5081663 IC50 = 1200.0 nM 5.92
CHEMBL5081574 IC50 = 1200.0 nM 5.92
CHEMBL5078658 IC50 = 1500.0 nM 5.82
CHEMBL5083737 IC50 = 1700.0 nM 5.77
CHEMBL5079544 IC50 = 2200.0 nM 5.66
CHEMBL396778 SAFINAMIDE IC50 - -