Assay Detail
Binding
CHEMBL5049242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 using 4-NBA and NADP+ as substrate by Michaelis-Menten based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldehyde dehydrogenase, dimeric NADP-preferring (CHEMBL3578) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.57 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5076191 | — | — | 1 | 6.62 |
| CHEMBL5082977 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5076191 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL5082977 | — | Ki | = | 300.0 | nM | 6.52 |