Assay Detail
Binding
CHEMBL5049503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-TEV-tagged human AChE expressed in CHO-K1 cells using acetylthiocholine iodide as substrate measured for 6 mins by Ellman's method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.26 | 4.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33051 | — | — | 1 | 4.26 |
| CHEMBL5084128 | — | — | 1 | - |
| CHEMBL5069796 | — | — | 1 | - |
| CHEMBL5088176 | — | — | 1 | - |
| CHEMBL1420 | PRALIDOXIME | 4.0 | 1 | - |
| CHEMBL291233 | OBIDOXIME CHLORIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33051 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL5084128 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL5069796 | — | IC50 | = | 1600000.0 | nM | - |
| CHEMBL5088176 | — | IC50 | = | 580000.0 | nM | - |
| CHEMBL1420 | PRALIDOXIME | IC50 | = | 560000.0 | nM | - |
| CHEMBL291233 | OBIDOXIME CHLORIDE | IC50 | = | 640000.0 | nM | - |